Estimate the midpoint and shape parameters for the logistic function used when simulating dropout.
splatEstDropout(norm.counts, params)
norm.counts | library size normalised counts matrix. |
---|---|
params | SplatParams object to store estimated values in. |
SplatParams object with estimated values.
Logistic function parameters are estimated by fitting a logistic function
to the relationship between log2 mean gene expression and the proportion of
zeros in each gene. See nls
for details of fitting.