A logistic function is used to form a relationshop between the expression level of a gene and the probability of dropout, giving a probability for each gene in each cell. These probabilities are used in a Bernoulli distribution to decide which counts should be dropped.

splatSimDropout(sim, params)

Arguments

sim

SCESet to add dropout to.

params

SplatParams object with simulation parameters.

Value

SCESet with simulated dropout and observed counts.